May 03, 2019 dengue is the most common and important arthropodborne viral arboviral illness in humans. A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage bleeding and circulatory collapse shock. It is transmitted by mosquitoes of the genus aedes, which are widely distributed in subtropical and tropical areas of the world see the image below. It is almost always responsive to appropriate antibiotics. A global strategy on dengue fever and dhf was developed in 1995 and its implementation was bolstered in 1999. Subsequently, the awareness of variable responses to the infection presenting. Mar 12, 2020 dengue is an infection caused by a virus. Infection with one serotype of denv provides immunity to that.
Aetiology,pathophysiology and diagnosis of dengue infection. Dengue hemorrhagic fever pathophysiology diagram free download as pdf file. The clinical picture and the pathogenesis of the severe disease are explained. Nov 14, 2006 dengue infection is caused by any of four dengue virus serotypes. However, since dengue shares clinical features with a wide variety of illnesses especially during the early febrile phase, large numbers of patients with possible dengue are often admitted to healthcare facilities in endemic areas, primarily for observation, and seasonal. Pathophysiology of dysentery what you need to know. These viruses are related to the viruses that cause the west nile infection and yellow fever.
Dengue diagnostics and dengue classificationcase management rapid diagnostic tests lateral flow tests for dengue antibodies lateral flow tests for antibodies to dengue provide the same information as elisas. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, and the following warning signs. The genetic variation in dengue viruses is region specific, suggestive that establishment into new territories is relatively infrequent, despite dengue emerging in new regions in recent decades. Bacterial dysentery is serious and can be life threatening. Dengue fever nursing care plan high risk for fluid. Dengue virus denv belongs to the family flaviviridae, genus flavivirus, and is transmitted to humans by aedes mosquitoes, mainly aedes aegypti. Come browse our large digital warehouse of free sample essays. We describe the virus characteristics and risk factors for dengue and dhf, and compare incidence and the case fatality rates in endemic regions southeast asia, western pacific, and the americas. Department of health and human services centers for. Pathogenesis of dengue haemorrhagic fever and its impact. The salient features of the resolution of the fortysixth world health assembly wha in. Scribd is the worlds largest social reading and publishing site. It would present with persistent diarrhea, sometimes bloody. Dengue chapter 4 2020 yellow book travelers health.
Endothelial cells elicit immuneenhancing responses to dengue virus infection n. In large part, this limitation is related to the lack of a suitable animal model of disease. Dengue and dengue hemorrhagic fever 1 dengue and dengue hemorrhagic fever information for health care practitioners dengue is a mosquitoborne disease caused by any one of four closely related dengue viruses denv1, 2, 3, and 4. The pathology of dengue hemorrhagic fever sciencedirect. Dengue fever has emerged as a global public health problem in the recent decades. Dengue is not included in the generic integrated management of childhood illness imci algorithm, but due to its importance, it was incorporated in several asian and latin american imci adaptations. The rapidly expanding global footprint of dengue is a public health challenge with an economic burden th. Beginning in the 1950s, at the time when four different denvs were discovered, a. Nov 19, 2007 risk factors for dengue hemorrhagic fever include having antibodies to dengue virus from prior infection and being younger than 12, female, or caucasian. Dengue virus inhibits the innate immune response in serval ways as discussed below. The clinical spectrum of the disease ranges from dengue fever to dengue hemorrhagic fever and dengue shock syndrome. Dengue is one of the most rapidly spreading vectorborne diseases in the world, with the incidence increasing 30fold in the past 50 years.
Pathogenesis of dengue haemorrhagic fever and its impact on. Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. Pathogenesis of vascular leak in dengue virus infection. Recent advances in dengue pathogenesis and clinical. Doctor answers on symptoms, diagnosis, treatment, and more. About 50100 million dengue fever infections occur every year in tropical and subtropical countries 2 see figure 1. Pathogenesis and pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Substantial gaps remain in the comprehensive understanding of the pathogenesis of dengue virus infections. Dengue viral infections represent one of the most rapidly emerging mosquito. Dengue ppt free download as powerpoint presentation. Dengue is the most common and important mosquitoborne viral infection and can manifest as dengue fever df, which is often a selflimiting febrile illness or less commonly dengue hemorrhagic fever dhf. Dengue hemorrhagic fever pathophysiology free download as word doc. Current concepts in dengue pathogenesis pdf 92p this note describes about the global impact of dengue and its epidemiology, the clinical presentation of acute dengue and the pathogenesis of acute dengue infection.
Introduction dengue the most important mosquitotransmitted viral disease in terms of morbidity and mortality dengue fever is a acute febrile syndrome occurring in tropical regions the virus causes increased vascular permeability that leads to a bleeding diathesis or disseminated intravascular coagulation dic known as dengue hemorrhagic fever dhf. The vaccine manufacturer, sanofi pasteur, announced in 2017 that people who receive the vaccine and have not been previously infected with a dengue virus may be at risk of developing severe dengue if they get dengue after being vaccinated. Transmission of denv has increased dramatically in the past two decades making denv the most important human pathogens among arthropodborne viruses 1. Dengue fever df is the fastest emerging arboviral infection spread by aedes aegypti. Jul 11, 2018 dengue part 1 pathophysiology by dr ariff arithra duration. Histologic, viral, and molecular correlates of dengue fever liver histopathology and biological correlates in five cases of fatal dengue fever in vietnamese children. Symptoms early symptoms of dengue hemorrhagic fever are similar to those of dengue fever, but after several days the patient becomes irritable, restless, and sweaty. Dengue hemorrhagic fever pathophysiology diagram scribd. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. Get the knowledge you need in order to pass your classes and more. Dengue pathogenesis, clinical manifestation, lab diagnosis. Rhesus monkeys develop viremia similar in pattern to humans after dengue virus challenge but do not develop clinical disease.
Pathophysiology of dengue fever 1 free download as word doc. Dengue hemorrhagic fever is a fatal manifestation of dengue virus that manifest with bleeding diathesis and hypovolemic shock. Coagulopathy in dengue infection and the role of interleukin6. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female aedes mosquitoes. Antibodydependent enhancement of disease and severe dengue. Much remains to be learned about the pathogenesis of the different manifestations of dengue virus denv infections in humans. Pathophysiology of severe dengue centers for disease.
Dec 07, 2018 dengue is also known as breakbone fever, hemorrhagic fever, dandy fever, infectious thrombocytopenic purpura. Please use one of the following formats to cite this article in your essay, paper or report. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. The earliest record found to date is in a chinese encyclopedia of disease, symptoms and remedies, edited in 610 a. Dengue is the most common and important arthropodborne viral arboviral illness in humans. Dengue infection is caused by any of four dengue virus serotypes. The latest publication from the institute of medical. It is an essential tool to take a look in a nursing care plan designeddengue fever nursing care planhigh risk for fluid volume deficit for. As both cell tropism and tissue tropism of denv are considered major determinants in the pathogenesis of. Plasma leakage and intrinsic coagulopathy are the pathological hall marks in dengue haemorrhagic fever dhf. Pathophysiology dengue hemorrhagic fever free download as word doc.
The major pathophysiologic hallmarks that distinguish dhf from df and other diseases are increased vascular permeability leading to plasma leakage and circulatory collapse dengue shock. Ive tried sifting through articles from the who, cdc, nih, medicinenet, etc. The incidence of dengue has increased dramatically in recent decades, with estimates of 40%50% of the worlds population at risk for the. Patients with dengue will have a history of living in, or recent travel to, a region where the disease is endemic. There are currently no licensed treatments or vaccines for dengue.
Known also as dengue hemorrhagic fever dhf, it starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat. Sep 17, 2010 aetiology, pathophysiology and diagnosis of dengue infection dr lee oi wah peg. The incidence of dengue has increased dramatically in recent decades, with estimates of 40%50% of the. The dengue cases studied during this epidemic were, as a whole, typical examples of the disease. Perubatan ud54 slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Current concepts in dengue pathogenesis pdf 92p download book. Dengue fever nursing care plan high risk for fluid volume. It is an essential tool to take a look in a nursing care plan designeddengue fever nursing care planhigh risk for fluid volume deficit for patients with dengue fever. Dengue hemorrhagic fever pathophysiology diagram free download as word doc. Apr 23, 2020 how to diagnose a case of dengue infection. Pathogenesis and pathophysiology of dengue hemorrhagic fever. Dengue is the most important mosquitobor ne viral disease of humans worldwide, with more than two billion people living in endemic areas and 50 to 100 million new infections occurring each year. The clinical manifestations range from asymptomatic infection to undifferentiated fever, dengue fever and dengue hemorrhagic fever d.
Dengue hemorrhagic fever nursing care management and study guide. Dengue fever is a mosquitoborne viral disease caused by 1 of 4 closely related but antigenically distinct serotypes of dengue virus, serotypes denv1. Inhibition of the human immune system by the dengue fever virus. Pdf autoimmune pathogenesis in dengue virus infection. Pathogenesis people bitten by aedes aegypti mosquito are diagnosed with high fever and severe joint pain that are the common symptoms of dengue fever 16. Dengue hemorrhagic fever nursing care management and study. Dengue part 1 pathophysiology by dr ariff arithra duration. National center for emerging and zoonotic infectious diseases. Pathology generalized vasculitis and effusion in serous cavities are important. The two major categories of stroke are ischaemic lack of blood and hence oxygen to an area of the brain and haemorrhagic bleeding from a burst or leaking blood vessel in the brain stroke. Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Learn more dengue clinical case management elearning pathophysiology of severe dengue. Anatomy and physiology dengue fever free download as word doc. They may range from subclinical infection to dengue fever, dengue hemorrhagic fever dhf, and eventually dengue shock syndrome dss. Health experts have known about dengue fever for more than 200 years. The importance of accurate diagnosis of dengue fever. Dengue virus and dengue pathophysiology part 2 youtube. In management of any disorder in medicine, diagnosis is a very important step. Viral virulence, infection enhancing antibodies, cytokines and chemical mediators in the setting of intense immune activation are the key players implicated in the pathogenesis of dhf. Pathology of dengue virus infection and dengue hemorrhagic. The incubation period is 314 days average, 47 days. Based on neutralization assay data, four serotypes denv1, denv2, denv3, and denv4 can be distinguished. Tests using recombinant viral envelope glycoproteins of dengue viruses 1, 2, 3, and 4, respectively, have been introduced. A stroke occurs when the blood flow to an area of the brain is interrupted, resulting in some degree of permanent neurological damage. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking.
Dengue pathogenesis, clinical manifestation, lab diagnosis and treatment. Although dengue is a very old disease but recently an alarming increase has been seen in the geographic range, along with the severity of. Pathophysiology dengue hemorrhagic fever virus scribd. Dengue is also known as breakbone fever, hemorrhagic fever, dandy fever, infectious thrombocytopenic purpura. Dengue has become a widespread infection over the past few year, extending from endemic to nonendemic areas. Dengue virus denv infections of humans were long thought to be selflimited and of low mortality. Dengue is an important differential diagnosis of fever in children presenting to firstlevel health facilities in tropical asia and latin america.
Pathophysiology of dengue hemorrhagic fever nursing. Symptoms include a high fever, headaches, joint and muscle pain, vomiting, and a rash. Pathophysiology and management of dengue hemorrhagic fever. Summary much remains to be learned about the pathogenesis of the different manifestations of dengue virus denv infections in humans. Dengue fever dengue hemorrhagic fever pathophysiology.